01

Research Overview

The Yang Lab is focused on studying the molecular mechanisms of cellular stress response pathways. We use an interdisciplinary approach, integrating structural biology (Cryo-EM/Cryo-ET), computational biology (de novo protein design) biochemistry (protein characterization), and cell biology (fluorescent imaging). Our goal is to modulate those stress response pathways in physiological and pathological conditions, potentially leading to the development of novel therapeutics for related human diseases, including neurodegeneration, metabolic disorders, and cancer. In addition, we have established close collaborations with experts in disease-relevant mouse models to complement our mechanistic findings.

02

Dr. Jie Yang

Dr. Yang earned his B.S. degree in Life Sciences from Wuhan University. From 2014 to 2019, He pursued his Ph.D. in biophysics at Case Western Reserve University in Cleveland, USA, focusing on studying the molecular mechanisms of inflammasome activation and pyroptotic cell death in innate immunity. From 2019 to 2024, Dr. Yang performed his postdoctoral research at the Scripps Research Institute in San Diego, where he studied the molecular mechanisms of mitochondrial stress response. In 2024, Dr. Yang establishes his independent research laboratory as a tenure-track assistant professor in the Department of Biochemistry and Molecular Genetics at the School of Medicine, University of Virginia.

03

The University of Virginia

Recognized as one of the top universities in the US, the University of Virginia is known as a member of the “Public Ivy” and one of the 25 members of the “New Ivy League.” The university consistently ranks among the top 30 best universities in the United States, holding the 24th position in the 2024 U.S. The School of Medicine hosts state-of-art facilities for conducting cutting-edge research, including a 300kV Titian Krios equipped with a K3 direct electron detector, a 200kV Glacios equipped with falcon4 direct electron detector, 200kV F20 and 120kV Spirit screening microscopes, and an Aquilos 2 Cryo-FIB. The Yang Lab has its own manual plunger installed for freezing cryo-EM grids efficiently.

04

Expected Candidates

Fellow with expertise in de novo protein design

Design novel binders to target biologically important protein complexes involved in cellular stress response.Develop methods harnessing protein design to advance high-resolution cryo-EM studies of challenging protein targets. This includes the design of scaffolds, fusion proteins, or binding partners to stabilize samples for structural determination.

Fellow with expertise in cryo-electron microscopy

Expertise in structural biology, molecular biology, or biochemistry

We also welcome applications from individuals interested investigating the fundamental aspects of any significant biological processes. Candidates with backgrounds and expertise in cell culture are preferred.

Those positions offer exciting opportunities to contribute to cutting-edge structural biology and protein engineering research in a collaborative environment. The lab is fully funded and offers competitive salary and benefits packages. More information about our research can be found on our lab website: https://jieyang-lab.com.

05

How to Apply

Please email a cover letter and CV to Dr. Yang at wfw7nc@virginia.edu.

 

 

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