崔畅分别于北京大学和伊利诺伊大学获得化学学士及博士学位，在麻省理工及哈佛大学从事博士后研究。2023年11月加入伊利诺伊大学香槟分校生物化学系，继续研究核糖核苷酸还原酶在体外及细胞内的机理与调控。近期工作请见：https://scholar.google.com/citations?user=2GSlqtQAAAAJ&hl=en&oi=ao

https://publish.illinois.edu/cuilabratory/openings/

未来主要研究方向包括：

金属及自由基活性中心的生物合成及修复

捕捉及表征活性蛋白复合体

筛选稳定抑制蛋白复合体的抑制剂

研究人员加入本实验室后，会学习多种金属酶学相关方法，包括但不限于冷冻电镜、光谱学、动力学方法、非天然氨基酸编码和细胞生物学。欢迎广泛化学、生物、物理学背景的同学申请。请感兴趣的同学联系changcui@illinois.edu并附简历。

Cui laboratory at the Department of Biochemistry at University of Illinois Urbana-Champaign is recruiting postdoctoral associate and graduate students to study the mechanism and regulation of human ribonucleotide reductase (RNR) in vitro and in vivo. RNR catalyzes the reduction of nucleotides to deoxynucleotides in almost all organisms to provide the building blocks for DNA synthesis and repair. The central role of RNR in nucleic acid metabolism makes it a promising target for cancer therapeutics and antimicrobial agents. Human RNR consists of α and β subunits which form dynamic complexes. Our laboratory aims to answer three major questions about human RNR and other homologs:

Study Fe2-Y• cofactor assembly and repair

Trap and characterize the active α/β complex

Target the inactive state for RNR inhibitors

01

Training that Cui Lab can offer

Over 1/3 of proteins contain metal cofactors, therefore, it is essential to understand the diversity and complexity of metalloenzymes, whether you are a chemist or biologist. We will use a variety of spectroscopic, structural, and kinetic methods to characterize RNR and other regulatory proteins containing metal cofactors.

Biophysical methods to characterize metalloenzymes

Kinetic methods to study enzyme mechanism

Genetic incorporation of unnatural amino acids

02

PI

Chang obtained her B.S. from Peking University and Ph.D. at University of Illinois at Urbana-Champaign and returned to her alma mater in November 2023 after postdoctoral training at MIT and Harvard University.

https://scholar.google.com/citations?user=2GSlqtQAAAAJ&hl=en&oi=ao

https://publish.illinois.edu/cuilabratory/openings/

03

Contact information

changcui@illinois.edu

 

 

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